Improvement of inflammatory bowel diseases based on expression and functional changes of P-glycoprotein by methylpredonislone and essential fatty acids

亚油酸和。-亚麻酸（α-LnA）可减少炎症性肠病（IBD）模型大鼠小肠对甲基强的松龙（MP）的吸收，并对MP具有大肠递送作用。LA和α-LnA具有抗炎作用，并对肠上皮细胞p -糖蛋白（P-gp）的表达和功能有调节作用。这表明，服用这些必需的不饱和脂肪酸不仅可以预防IBD的进展，还可以使体内P-gp底物药物的肠道吸收和处置正常化。更多的实验信息和数据对于IBD治疗中更有效的给药计划是必要的。

Linoleic acid(LA) and.-linolenic acid(α-LnA) decrease the absorption of methylpredonisolone(MP) from small intestine in inflammatory bowel disease(IBD) model rats and have delivery effects to large intestine to MP. LA and α-LnA have anti-inflammatory effects and regulatory effects on expression and function of P-glycoprotein(P-gp) in intestinal epithelial cells. It suggests that administration of these essential unsaturated fatty acids not only prevent progress of IBD and also normalize intestinal absorption and disposition of the drug which is a substrate of P-gp in vivo. More experimental information and data are necessary for more efficient administration schedule of drugs in IBD therapy.