Novel role of neuronal Ca^<2+> sensor-1 as a regulator of cardiac function

细胞内Ca^<2+>在调节心脏兴奋-收缩偶联（EC）和肥大中起关键作用。在未成熟的心脏中，肌浆网（SR）的结构和功能是不成熟的;尽管如此，它被认为是收缩的Ca^<2+>的主要来源，这表明存在缺失的促进SR依赖性EC偶联的因子。我们发现，神经元Ca^2+传感器-1（NCS-1）是一种小的Ca^2+结合蛋白，其在心脏中的功能尚不清楚，它是一种增强未成熟心脏中Ca^2+信号和收缩的调节剂。此外，NCS-1表达在成人心脏肥大的早期阶段增加，并促进肥大的进展。

Intracellular Ca^<2+> plays key roles in regulating excitation-contraction coupling(EC) and hypertrophy in the heart. In the immature heart, the structure and function of sarcoplasmic reticulum(SR) is immature ; nonetheless, it is considered a primary source of Ca^<2+> for contraction, suggesting the existence of missing factors that promote SR-dependent EC coupling. We showed that neuronal Ca^<2+> sensor-1(NCS-1), a small Ca^<2+> binding protein, which functions in the heart were unknown, is one such regulator that enhances Ca^<2+> signals and contraction in the immature heart. In addition, NCS-1 expression increases in the early stages of hypertrophy in the adult heart and promotes progression of hypertrophy.