Elucidation of mechanism of cytomegalovirus reactivation and infection in inflammatory bowel disease.

巨细胞病毒（CMV）感染巨噬细胞的功能分析。巨细胞病毒再激活的巨噬细胞比没有巨细胞病毒再激活的巨噬细胞强烈地产生更多的促炎细胞因子。TGF-β不能抑制巨细胞病毒再激活的巨噬细胞产生促炎细胞因子，因为这些细胞中的Smad信号转导被阻断。(2)阐明IBD患者肠道CMV感染的机制。与非炎症结肠黏膜相比，炎症结肠黏膜中PDGFR等可能是CMV进入部位的基因表达上调。有趣的是，免疫组织化学研究显示，巨细胞病毒主要感染于肠间充质细胞。

Analysis of function of macrophages infected with cytomegalovirus(CMV). Macrophages, in which CMV was reactivated, strongly produced more pro-inflammatory cytokines in comparison with macrophages with no CMV reactivation. TGF-βdid not inhibit pro-inflammatory cytokine production from macrophages with CMV reactivation because Smad signal transduction was blocked in those cells.(2)Elucidation of mechanism of CMV infection in intestine of IBD. Gene expressions of PDGFR, etc., which could be entry site of CMV, were up-regulated in inflamed colonic mucosa in comparison with non-inflamed colonic mucosa. Interestingly, immunohistochemistry study revealed that CMV is mainly infected in mesenchymal cells of intestine.