The effects of fatty acid emulsion for cisplatin-induced acute renal failure in rats

本研究制备了二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的可输注乳剂，并观察了该乳剂对顺铂诱导的大鼠急性肾功能衰竭模型的影响。然而，在模型中没有乳剂的有益作用。并观察DHA乳剂对大鼠肾毒性血清肾炎模型的影响。乳剂给药后，大鼠尿蛋白排泄水平降低。这些结果表明，DHA乳剂可能对肾脏疾病有益。

In this study, we created an infusible emulsion of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and investigated the effect of the emulsion against cisplatin-induced acute renal failure model of rats. However, there were no beneficial effect of the emulsion in the model. We also investigated the effect of DHA emulsion against nephrotoxic serum nephritis model of rats. After the administration of the emulsion, the levels of protein excretion of urine were decreased in the rats. These results suggest that DHA emulsion might be beneficial effects for the renal disease.