The role of plasmin in the regulation of the multiple myeloma microenvironment

细胞外调节因子之一是金属蛋白酶（MMPs）。MMP激活可促进造血生长因子的分泌，进而推动造血细胞分化为cd11b阳性F4/80 bm源性细胞。这些血管增强细胞可以被招募到各种肿瘤床，进一步加速肿瘤生长所必需的血管化。此外，这些bm来源的细胞是MMPs的主要生产者，形成恶性循环，加速肿瘤细胞的生长。在这个应用中，我建议蛋白酶可以成为治疗血液肿瘤相关疾病包括骨髓瘤的一个新的分子靶点。

One of the outside cellular regulators are metalloproteinases(MMPs). MMP activation can promote the secretion of hematopoietic growth factors, which in turn drive hematopoietic cell differentiation into e. g. CD11B-positive F4/80 BM-derived cells. These angiopotent cells can be recruited into various tumor beds to further accelerate vasuarization necessary for tumor growth. In addition, these BM-derived cells are major producers of MMPs, creating a vicious cycle accelerating tumor cell growth. In this application, I suggest that proteases can become a novel molecular target in the treatment of blood tumor-related disease treatment including myeloma.