A multicenter study on early diagnosis and prognostic prediction of acute encephalopathy in childhood

对儿童脑病及相关疾病早期尿β-2-微球蛋白(BMG)水平进行多中心研究。在脑病(A组)、复杂热性惊厥(B组)和行为异常(C组)患者中，平均BMG水平以A组最高，B组次之，但3组间BMG水平无显著差异。未观察到脑病类型与尿BMG水平的相关性。大多数尿BMG水平极高的患者有致命结局或严重后遗症。在脑病患者中，死亡病例和严重后遗症患者尿BMG水平明显升高，提示早期尿BMG水平升高是预后不良的因素。

A multicenter study to evaluate urineβ2-microglobulin(BMG) levels at early phase of childhood encephalopathy and related disorders was performed. Among patients with encephalopathy(Group A), complex febrile convulsion(Group B) and abnormal behavior(Group C), mean BMG level was highest in Group A, followed by Group B. However, BMG levels were not significantly different among the 3 groups. Correlation between types of encephalopathy and urine BMG levels was not observed. Most of the patients showing extremely high level of urine BMG had fatal outcome or severe sequelae. Among the patients with encephalopathy, urine BMG levels were significantly higher in fatal cases and cases with severe sequelae, indicating that elevated urine BMG level at early phase was a poor prognostic factor.