Electrophysiological studies of myoclonus "during wakefulness" for understanding the pathophysiology of akathisia.

本研究期间住院的患者总数为132人。132例住院患者中有27例根据DSM-IV诊断标准诊断为精神分裂症。27例患者中有4例在住院期间表现出静坐不能。研究期间精神分裂症患者总数为55人，平均年龄为37岁。在55名精神分裂症患者中，静坐不能患者共11人。静坐不能的发生率为20。0%整体。益肝散（7. 5 g/d，餐前3次/d）给药于3例静坐不能按静坐不能治疗指南治疗后仍无改善的患者。此外，对上述三例患者给予益肝散治疗后，静坐不能仍无改善。多导睡眠图24例。在其中三个病例中，可以使用摄像机进行拍摄，因此，患者能够在“清醒时”提取肌阵挛，这仅在三个病例中发生。原定计划和目标的实现程度有所延迟。所有符合条件的患者在研究期间之前已经开始服用多种类型的抗精神病药物，因此静坐不能的发生率不能归因于“清醒时肌阵挛”患病率的简单比较。

The total number of patients who were admitted to the hospital during this study was 132 people. 27 people of the 132 hospitalized patients had been diagnosed with schizophrenia based on the DSM-IV diagnostic criteria. Four out of the 27 patients expressed akathisia during the hospitalization. The total number of patients with schizophrenia during this study period was 55 people with an average age of 37 years. The akathisia patients totaled 11 people of the 55 people with schizophrenia. The incidence of akathisia was 20. 0% overall. Yi-gan san(7. 5g/day, 3times/day before meals) was administered to three patients whose akathisia did not improve when using akathisia treatment guidelines. In addition, akathisia did not improve even after the administration of Yi-gan san to the three mentioned patients. Examples of polysomnography were 24 cases. In three of these cases it was possible to shoot using a video camera.Therefore, the patient was able to extract myoclonus "during wakefulness" this being the case in only three cases. The level of achievement against the original plan and purpose was delayed. All eligible patients had already started taking many types of antipsychotic drugs before the study period, and therefore the incidence of akathisia could not be due to a simple comparison of the prevalence of "myoclonus during wakefulness".