Evaluation of improved therapeutic effect of radioisotope therapy combining targeted inhibition of amino acid transporter.

用Ki-67标记指数评价头颈癌患者18F-AMT摄取与细胞生长活性的相关性。结果表明，这两个指标之间存在显著的相关性。在131I-MIBG治疗方面，通过检测注射131I-MIBG后1周的血浆儿茶酚胺来评价早期疗效，血浆儿茶酚胺水平与早期疗效显著相关。比较了FDG-PET/CT、123I-MIBG核素显像和X线CT在评价131I-MIBG疗效中的诊断价值，证实了FDG-PET/CT在评价131I-MIBG治疗恶性嗜铬细胞瘤疗效中的价值。

Correlation of 18^F-AMT uptake and cellular growth activity evaluated by Ki-67 labeling index was assessed in patients with head and neck cancer. As a result, significant correlation of both indexes was confirmed. As for 131^I-MIBG therapy, the early therapeutic response by the measurement of serum catecholamine 1 week after injection of 131^I-MIBG was assessed and serum catecholamine is proved to be significantly related with better response. Furthermore, diagnostic utility of FDG-PET/CT comparing with 123I-MIBG scintigraphy and X-ray CT in the evaluation of therapeutic effect of 131^I-MIBG was assessed and it is confirmed that FDG-PET/CT is useful in the evaluation of therapeutic response of 131^I-MIBG in malignant pheochromocytoma.