Functional and morphological integrated assessments of hepato-biliary-pancreatic carcinomas using 320 detector-row CT

我们评估了新开发的面积探测器CT在上腹部器官功能和疾病的功能和形态评估中的作用。面检CT对腹部细小血管的显示优于常规CT。我们开发了腹部功能(灌注)CT扫描方案和对比剂注射方案、呼吸错误配准校正软件和三种不同分析方法的灌注分析软件。结果表明，CT灌注成像中的照射量可减少到常规方法的1/3，对比剂的体积和注射速度可减少到常规方法的1/3，3 cm以下的呼吸配准错误可得到满意的纠正。已发现心功能的影响，需要予以补偿。在腹部疾病患者中，我们发现了新的发现，如器官之间的血流灌注相互作用和有助于诊断恶性肿瘤的血流灌注参数。研究还发现，CT灌注成像可用于评估肿瘤放疗后的疗效、抗癌药的使用情况以及残留器官功能。本研究结果提示，在评价上腹部器官功能和疾病方面，采用面检CT的功能和形态综合CT优于常规的形态CT。

We evaluated newly-developed Area-Detector CT in functional and morphological assessments of the upper abdominal organ function and diseases. Area-Detector CT was superior to conventional CT in assessment of fine abdominal vessels. We developed CT scanning protocol and injection protocol of contrast medium for abdominal functional(perfusion) CT, correction software for respiratory misregistrations, and software for perfusion analysis with three different analytic methods. Our results showed irradiation during perfusion CT can be reduced to 1/3 and volume and injection rate of contrast medium can be reduced to 1/3 of those in the conventional methods and respiratory misregistrations less than 3 cm can be satisfactorily corrected. Effects of cardiac function were found and it needs to be compensated. In patients with abdominal diseases, we found new findings such as interactions in blood perfusion among the organs and useful perfusion parameters for diagnosis for malignant tumors. It was also found that perfusion CT is useful for assessment of tumor responses after radiotherapy and anticancer agents as well as residual organ function. The results of this study suggest functional and morphological integrated CT using Area-Detector CT can be superior to those of conventional morphological CT in assessments of the upper abdominal organ function and diseases.