Regenerative repair of bone defeots with osteoinduotive hydroxyapatite fabr icated to match the defect and implanted with combined use of computer-aided design, computer-aided manufaoturing, and computer-assisted surgery systems : a feasibility study in a

目前，大块骨的再生修复检测是一个具有挑战性的问题。本研究的目的是实现大型骨缺损的修复，使其恢复到原来的三维解剖状态。在3D图像上，将假想的恶性骨肿瘤放置在犬的左侧髂骨中。术前应用计算机辅助设计软件计划全瘤切除。在计算机图像上构建用于填充由此产生的骨缺损的植入物的图像。利用计算机辅助制造系统制作了与成像骨缺损区相同的多孔羟基磷灰石植入物。术前在3ct图像上按计划切除髂骨，进行计算机辅助手术。用自制的种植体填充缺损处，并用含有BMP-2的油灰载体涂层，在CT图像上发现每个种植体周围有新的骨形成，并在系列CT图像上重建以恢复髂骨的原始解剖结构。这种新的方法可以在不植骨的情况下，有效地、精确地再生修复大段骨缺损。

Currently, regenerative repair of large bone detect is a challenging issue. The aim of this study was to achieve repair of large bone defects to the original three-dimensional(3D) anatomical state. An imaginary spherical malignant bone tumor of was placed in the left ilium of a canine on the 3D imaue. Resection of the whole tumor was planned preoperatively by using computer-aided design software. An image of the implant to fill the resulting bone defect was constructed on the computer image. A porous hydroxyapatite implant identical to the imaged bone defect was made with a computer-aided manufacturing system. To resect the iliac bone as planned preoperatively on the 3^CT image, computer-aided surgery was performed. The defect was filled with the fabricated implant and coated with a putty carrier with BMP-2.New bone formation was noted around each implant on CT images and remodeled to restore the original anatomy of the ilium on serial CT images. This new method may enable efficacious and precise regenerative repair of large bone defect without bone grafting.