Identification of osteoblast function regulating factor secreted by human mesenchymal stem cell

我们在体外研究了人骨髓间充质干细胞衍生成骨细胞在钙化过程中是否会诱导细胞死亡，以及死亡细胞是否参与了钙化过程。我们的研究结果表明，在体外成骨培养中，间充质干细胞可诱导细胞死亡，并提示caspase非依赖性死细胞和/或成骨细胞谱系的坏死死细胞可能参与骨钙化的机制。

We investigated whether cell death is induced during the calcification process by osteoblast derived from human bone marrow mesenchymal stem cells in vitro, and whether dead cells are involved in the calcification process. Our findings showed that cell death was induced in osteogenic culture of mesenchymal stem cells in vitro, and suggested that caspase-independent dead cells and/or necrotic dead cells of osteoblast lineage might be involved in the mechanism of bone calcification.