Isoflurane-induced postconditioning is mediated by activation of mitochondrial calcium-activated potassium channels

挥发性麻醉药异氟醚具有麻醉后处理作用，可诱导对心肌缺血和再灌注损伤的心脏保护作用。我们证明，线粒体钙激活钾通道的激活在这些行动中起着关键作用。此外，我们发现，挥发性麻醉药诱导的线粒体蛋白的调节O-连接的β-N-乙酰葡萄糖胺也有一个重要的挥发性麻醉药诱导的心脏保护。

Volatile anesthetics isoflurane have an anesthetic postconditioning effects that induce cardioprotective effects against myocardial ischemia and reperfusion injury. We demonstrated that activation of mitochondrial calcium-activated potassium channels play a pivotal role on these action. Furthermore, we showed that volatile anesthetics induced modulation of mitochondrial protein by O-linked beta-N-acetylglucosamine also have an important for volatile anesthetics induced cardioprotection.