Role of endogenous prostanoids in vascular remodeling

野生型（WT）和EP4受体敲除（EP4^<-/->）小鼠左颈总动脉结扎两周后，内膜区域和内侧区域均增加。与EP4^<-/->动脉相比，结扎后四周WT动脉的内膜面积显著增加。与EP4^<-/->动脉相比，结扎后WT动脉的I/M比和狭窄比在血流停止后4周也显著增加。这些结果表明内源性PGE2通过EP4受体在血流停止引起的内膜增生中起重要作用。

The intimal areas and medial areas two weeks after ligation of left common carotid arteries increased in both wild-type (WT) and EP4 receptor knockout (EP4^<-/->) mice. The intimal area four weeks after ligation was significantly increased in the ligated WT arteries compared with EP4^<-/-> arteries. I/M ratio and stenotic ration four weeks after blood flow cessation were also significantly increased in the ligated WT arteries compared with EP4^<-/->arteries. These results indicate that endogenous PGE2 plays an important role in intimal hyperplasia caused by blood-flow cessation via EP4 receptor.