Identification of androgen-response genes related with the proliferation and development of proliferation-related marker in prostate cancer

我们试图鉴定影响前列腺癌增殖的基因中雄激素受体的敏感性。我们用正常组织与前列腺穿刺活检获得的前列腺癌组织的基因表达谱进行了比较。然后我们关注CAMKK2在癌症患者中这些基因的表达增加了大约6倍。在雄激素敏感的前列腺癌细胞LNCaP中，DHT诱导CAMKK2表达。在前列腺组织免疫组化染色和体外研究中，CAMKK2作为抗原基因发挥作用。

We tried identification to affect the androgen receptor sensitivity in the gene which affected the proliferation of the prostate cancer. We compared a gene expression profile by cDNA microarray which we used a normal tissue for with the prostate cancer tissue by several obtained by prostatic needle biopsy. Then we focused on CAMKK2 which the approximately 6 times expression enhanced in patients with cancer in those genes. As for CAMKK2, expression was induced in androgen-sensitive prostate cancer cell line LNCaP by DHT. In immunohistochemical staining of the prostatic tissue and in vitro study, CAMKK2 functioned as antioncogene.