Regenerative medicine for diabetic polyneuropathy using dental pulp stem cells

在这项研究中，我们研究了移植大鼠或人DPSCs是否能改善糖尿病多发性神经病变。将DPSCs注射到链丙佐菌素诱导的糖尿病动物单侧后肢骨骼肌中。DPSCs移植改善了糖尿病患者感觉、坐骨神经传导速度和坐骨神经血流量的下降。免疫组织学研究显示，移植后的DPSCs存在于肌周束区，未分化为成骨细胞和脂肪细胞。这些结果表明，DPSCs是一种有前景的再生医学细胞来源，其移植可能是治疗糖尿病多发性神经病变的一种新方法。

In this study, we examined whether transplantation of rat or human DPSCs improve diabetic polyneuropathy. DPSCs were injected into unilateral hindlimb skeletal muscles of streprozotocin-induced diabetic animals. Transplantation of DPSCs ameliorated the decrease of sensation, sciatic nerve conduction velocity and sciatic nerve blood flow under the diabetic condition. Immunohistological study revealed that transplanted DPSCs existed in perimuscle bundle area without differentiation into osteoblasts or adipocytes. These results indicate that DPSCs are promising cell source for regenerative medicine and the transplantation of DPSCs may be a new therapy for diabetic polyneuropathy.