Mechanisms of T cell function disorder in periodontal diseases by butyrate and gingival fibroblast

本研究旨在探讨牙周成纤维细胞在牙周病原菌分泌的丁酸引起的牙周组织免疫反应损伤中的作用。提示牙周病患者制备的对丁酸依赖性细胞死亡敏感的GF不能抑制丁酸依赖性T细胞的死亡。相反，丁酸抗性的健康GF抑制T细胞的细胞死亡。此外，丁酸修饰的细胞因子从辅助性T细胞亚群产生不依赖于GF。这些结果可能暗示了牙周病细菌和丁酸盐损害牙周组织免疫反应的其他机制。

This study focused on the effect of gingival fibroblasts (GF) on impairment of immune responses in periodontal tissues caused by butyrate secreted from periodontopathic bacteria. It was suggested that GF which was prepared from periodontal diseases patients and sensitive to butyrate-dependent cell death failed to inhibit the butyrate-dependent cell death of T cells. On the contrary, butyrate-resistant healthy GF suppressed the cell death of T cells. Moreover, butyrate modified cytokine production from helper T cell subsets independently of GF. These results may imply additional mechanisms by which periodontopathic bacteria and butyrate impair the immune responses in periodontal tissues.