Molecular mechanisms of subcellular synapse organization in cerebellar Purkinje neurons

神经元布线的一个显著特征是其特异性。小脑内的信息处理过程中，小脑内的谷氨酸能和γ-氨基丁酸能输入沿着浦肯野神经元的亚细胞结构是必不可少的。在这项研究中，我们证明，RBP-J促进星状细胞和篮状细胞的神经发生：两套抑制性神经元，分别支配选择性树突和轴突的浦肯野神经元的初始段。另外。结果发现，在Z+区，支配浦肯野神经元近端树突的爬行纤维（CF_s）比Z-区的CF释放概率高。

A remarkable feature of neuronal wiring is its specificity. The subcellular organization of glutamatergic and GABAergic inputs along Purkinje neurons is essential for information processing in cerebellum. In this study, we demonstrated that RBP-J promotes the neurogenesis of stellate and basket cells : two sets of inhibitory neurons that innervate selectively dendrites and axonal initial segments of Purkinje neurons, respectively. In addition. I found that climbing fibers(CF_s) that innervate proximal dendrites of Purkinje neurons in zebrin II immunoreactive(Z+) zones have a higher release probability than CFs in Z-zones.