Study of organ crosstalk associated with adipose tissue in the fetal origins of adult disease

对宫内营养不良的小鼠动物模型的研究表明，追赶生长过程中的瘦素分泌调节成年后的胰岛素敏感性，婴儿的生长发育与白色脂肪组织慢性炎症的各种参数作为代谢综合征的风险呈正相关。在人类队列研究方面，我们完成了滨松出生队列(HBC)1200名孕妇的进入，现在正在对她们的孩子进行随访。

The study of mouse animal model of undernourishment in utero reveled that leptin secretion during catch-up growth regulates insulin sensitivity in adulthood and that growth of infant positively correlates with the various parameters of chronic inflammation in white adipose tissue as a risk of metabolic syndrome. As for human cohort study, we finished the entry of 1, 200 pregnant women in Hamamatsu Birth Cohort(HBC) and now carry out following up of their children.