A translational research for promotion of multimodality therapy combined with proton beam therapy

这项研究的目的是促进多模式治疗与质子束治疗(PBT)相结合的翻译研究。我们发现Bragg峰晚期的放射生物学效应增强，并在极低剂量的质子照射下检测到隐窝细胞的凋亡。对于正常的组织反应，无论是肝癌的PBT肋骨骨折，还是晚期肺癌PBT联合化疗的肺炎，都存在明显的剂量-体积关系。最后，通过这些转化性研究，我们已经开始了晚期肺癌和儿童癌症的临床试验，作为一种结合PBT的多模式治疗。

The aim of this study is to promote translational research for multimodality therapy combined with proton beam therapy (PBT). We found increasing radiobiological effect on late phase of bragg peak, and also detected apoptosis in the crypt cells irradiated with very low dose of proton. For normal tissue reaction, dose-volume relationship was clearly found both in rib fracture on PBT for liver cancer and in pneumonistis on PBT combined with chemotherapy for advanced lung cancer. Finally, from these translational researches, we have started clinical trials for advanced lung cancer and pediatric cancer as a multimodality therapy combined with PBT.