Analysis of quorum sensing induced analogs in situ in human dental biofilms

本研究旨在建立对人牙生物膜的化学防治方法。以n -酰基同型丝氨酸内酯（AHL）类似物作为自诱导剂和群体感应（QS）诱导剂为研究对象。10种AHL类似物均未超过检出限(6。32-7。33 ng/ ml)，说明AHL在人牙生物膜中几乎不存在。另一方面，我们发现了一些AHL类似物和抗生素具有影响QS的抗生物膜作用，为这些化疗药物的化学生物膜控制方法的临床应用奠定了基础。我为这些研究结果感到自豪，为开发新的细菌生物膜病治疗策略提供了重要的建议。

This study was carried out for the establishment of the chemical control and restraint method against human dental biofilm. N-Acyl homoserine lactone(AHL) analogs which was one kind of the autoinducer and was quorum sensing(QS) inducer were targeted. The 10 kinds of AHL analogs were not shown above detection limit(6. 32-7. 33 ng/ ml), and it was clarified that AHL hardly existed in human dental biofilm. On the other hand, We discovered some AHL analogs and antibiotics indicating the anti-biofilm action that would affect QS and made the basics for the clinical application of the chemical biofilm control method by these chemotherapeutic agents.I take pride in these results of the research giving a significant suggestion for the development of the new treatment strategy of the bacterial biofilm disease.