Development and in-vivo application of functional manganese-enhanced MR molecular imaging

本文探讨了锰造影剂（Mn^<2+>）的分子机制及其在以下方面的应用：1）新生儿放射性脑畸形模型的定量评价; 2）肿瘤细胞中Mn蓄积的定量观察及其在高Mn-SOD表达的间皮瘤模型中的应用; 3）Mn^<2+>标记单核细胞的开发及其在体内的应用。具有高场和定量MRI的阳性造影剂Mn^<2+>可以提供有希望的体内分子成像以非侵入性地评估细胞水平改变或疾病。

Molecular mechanism of manganese contrast agent(Mn^<2+>) was investigated, as well as following applications : 1) quantitative evaluation for microencephaly model by neonatal radiation, 2) quantitative observation of Mn accumulation in tumor cells and application for higher Mn-SOD expressed mesothelioma model, 3) development and in-vivo application of monocyte labeling using Mn^<2+>. Positive contrast agent, Mn^<2+>, with high field and quantitative MRI can provide promising in-vivo molecular imaging to assess cellular level alteration or disease non-invasively.