Identification of a factor which improves the differentiation ability of a stem cell
Identification of a factor which improves the differentiation ability of a stem cell
批准号:
21790300
负责人:
HIKICHI Takafusa
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
虽然将核移植前后表达增加的基因的siRNA分别导入正常受精胚胎自然干细胞(ES),但在体外对神经细胞的分化能力没有观察到变化。而孤雌胚胎的胎盘在使用核移植技术开发时可以逃脱表观遗传调控,并可以支持胎儿发育到完全怀孕。
英文摘要
Although siRNA to the gene which the amount of expression increased before and after the nuclear transplantation was introduced into the normal fertilized embryo nature stem cell (ES), respectively, change of the differentiation ability to the nerve cell in in vitro was not observed. And the placentas of parthenogenetic embryos can escape epigenetic regulation when developed using nuclear transfer techniques and can support fetal development to full gestation.
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会议论文
DOI:
10.1242/dev.051375
发表时间:
2010-09-01
期刊:
DEVELOPMENT
影响因子:
4.6
作者:
[Hikichi, Takafusa, Ohta, Hiroshi, Wakayama, Teruhiko]
通讯作者:
Wakayama, Teruhiko
海外基金