Development of reconstruction scaffold for jaw bone made of titanium fiber web with cell induction ability

本研究的目的是利用分子前驱体法评价涂覆薄羟基磷灰石（HA）层钛纤维网（TW）的骨再生性能。采用分子前驱体法在钨上均匀地涂覆了一层透明质酸薄膜，而不影响钨的结构。在TW和HA包被的TW （HA/TW）上培养的人成骨细胞表明，分子前体方法包被的HA维持了TW的结构，加速了成骨细胞的分化。然后，将带或不带薄羟基磷灰石涂层的TW椎间盘植入大鼠颅骨皮质骨缺损，提示薄羟基磷灰石涂层通过维持TW孔隙度和促进TW三维支架的骨导电性来促进皮质骨形成。

The aim of this study was evaluation of the bone regeneration properties of titanium fiber web (TW) that had been coated with a thin hydroxyapatite (HA) layer using the molecular precursor method. A thin HA film was uniformly coated on a TW by the molecular precursor method, without affecting the structure of the TW. Human osteoblasts culture on TW and HA-coated TW (HA/TW) suggested that the HA coated by the molecular precursor method maintained TW architecture and accelerated osteoblast differentiation. Then, TW discs with or without thin HA coating were implanted into rat cranial cortical bone defects, suggesting a thin HA coating enhanced the cortical bone formation through maintenance of TW porosity and promotion of osteoconductivity in the TW 3-dimensional scaffold.