A novel strategy for heat stroke: Transplantation of mesenchymal stem cells

本研究的目的是评估中暑后内皮细胞的病理生理和再生反应，并检查间充质干细胞在大鼠模型中的作用。血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6、可溶性血栓调节蛋白和可溶性内皮选择素浓度在中暑后3和6小时显著升高。在肺中，在中暑后6小时观察到间质水肿、肺泡腔结构破坏和肺泡内出血。进行间充质干细胞的移植以评估抑制炎性细胞因子的产生、保护内皮损伤和改善热应激大鼠模型中的存活的效果。

The objectives of this study were to evaluate the pathophysiology and regenerative response of endothelium after heat stroke and to examine the effects of mesenchymal stem cells in a rat model. The serum concentrations of tumor necrosis factor alpha (TNF-α), interleukin-6, soluble thrombomodulin, and soluble endothelial selectin significantly increased at 3 and 6 hours after heat stroke. In the lung, interstitial edema, structural disruption of the alveolar lumen, and intra-alveolar hemorrhage were observed at 6 hours after heat stroke. Transplantation of mesenchymal stem cells was conducted to evaluate the effects to inhibit the production of inflammatory cytokines, protect against endothelial damage and improve survival in a rat model with heat stress.