Molecular mechanisms and regulation of DGK-related physiological functions and refractory diseases

二酰基甘油（DG）激酶有十个同工酶。我们最近发现DGK同工酶在多种信号转导途径中发挥关键作用，并参与难治性疾病的发病机制。因此，我们计划揭示DGK同工酶调控信号转导通路的机制及其新的病理生理功能。为此，我们首先建立了几种新的分析方法。此外，我们还获得了关于DGKα、γ、δ和η的病理生理功能和活性调节的有趣结果。

Diacylglycerol (DG) kinase has ten isozymes. We have recently found that DGK isozymes play pivotal roles in a wide variety of signal transduction pathways and are involved in pathogenesis of refractory diseases. Thus, we planed to reveal the mechanisms of regulation of signal transduction pathways by DGK isozymes and their novel patho-physiological functions. To this end, we first established several new analytical methods. Moreover, we obtained interesting results concerning the patho-physiological functions and the activity regulation of DGKα, γ, δ and η.