Pharmacogenomic study on the drug-sensitive genes using model organisms

在本研究中，我们进行了许多实验，以阐明药物不良反应的分子机制，以及克服耐药性。为此，我们对对各种药物表现出过敏性或抗药性的各种分裂酵母突变株进行了遗传分析。结果，我们确定了导致药物敏感性变化的各种基因。这些结果将有助于减少免疫抑制剂的不良反应，寻找新的抗真菌药物靶标分子，克服耐药性，或寻找丙戊酸的新临床应用。

In this study we performed many experiments to clarify the molecular mechanisms of adverse action of drugs as well as to overcome the drug resistance. For this purpose we genetically analyzed various fission yeast mutant strains that show hypersensitivity or resistance to various drugs. As results, we identified various genes that are responsible for the changes in the drug sensitivity. These results will be helpful to reduce the adverse effects of immunosuppressants, to identify novel target molecules for antifugal drugs, to overcome the drug resistance, or to find a new clinical application of valproic acid.