Cytoprotective effects of bioactive molecules derived from bacteria in the intestinal biofilm

本研究通过对人类和小鼠样本的分析，确定了肠腔和生物膜中以及健康志愿者和IBD患者之间微生物群的变化。本研究表明，益生菌衍生效应物对肠道炎症引起的肠道损伤具有保护作用。这些功能是由益生菌衍生的效应物与转运体或粘附分子之间的相互作用介导的。这些结果将有助于开发利用益生菌衍生效应剂治疗肠道炎症的新方法。

The present study identified the alterations in the microflora in the intestinal lumen and biofilms, and between healthy volunteers and IBD patients based on an analysis of human and mouse samples. This study showed that probiotics-derived effectors exhibited protective effects against intestinal injury due to intestinal inflammation. The functions were mediated by the interaction between the probiotic-derived effectors and transporters or adherent molecules. These results will be helpful for the development of a novel treatment for intestinal inflammations using probiotic-derived effectors.