Development of tailor made peptide vaccines for renal cell carcinoma
Development of tailor made peptide vaccines for renal cell carcinoma
批准号:
22390305
负责人:
UEMURA Hirotsugu
金额:
$12.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
我们一直致力于开发新的mhc - i类限制性肽疫苗,用于五个独立的治疗靶点,并已确定了一个重要的候选EPORxx。我们正在准备申请这种特殊肽疫苗的专利。我们还对18例弥散性肾细胞癌患者进行了VEGFR1肽疫苗的i /II期临床研究,显示了疫苗接种治疗的安全性和有效性。
英文摘要
e have been working on the development of new MHC-class-I restricted peptide vaccines for five independent therapeutic targets and have identified a significant candidate EPORxx. We are preparing the application of a patent for this particular peptide vaccine. We also carried out phase-I/II clinical study with VEGFR1 peptide vaccines for 18 patients with disseminated renal cell carcinoma, and showed the safty and efficacy of the vaccination treatment.
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Assessment of immunological biomarkers in patients with advanced capcer treated by personalized peptide vaccination.
通过个性化肽疫苗接种治疗的晚期 capcer 患者的免疫生物标志物评估。
DOI:
--
发表时间:
2010
期刊:
Cancer Biol Ther.
影响因子:
--
作者:
[Noguchi M., Uemura H., et al.]
通讯作者:
et al.
Clinical role of MHC-class I peptide vaccines for metastatic renal cell carcinoma
MHC I 类肽疫苗治疗转移性肾细胞癌的临床作用
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[T Minami, T Minami, N Shimizu, Y Yamamoto, M De Velasco, T Hayashi, M Nozawa, K Yoshimura, T Ishii, H Uemura]
通讯作者:
H Uemura
DOI:
10.1093/jjco/hyq127
发表时间:
2010-09-01
期刊:
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
影响因子:
2.4
作者:
[Naito, Seiji, Tomita, Yoshihiko, Wahid, Mohamed Ibrahim Bin A.]
通讯作者:
Wahid, Mohamed Ibrahim Bin A.
転移性腎がんに対するMHC クラスI ペプチドワクチン療法の役割
MHC I 类肽疫苗治疗在转移性肾癌中的作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[植村天受, 吉村一宏, 南 高文, デベラスコ マルコ]
通讯作者:
デベラスコ マルコ
A phase I trial of VEGFR1 peptide vaccines for patients with metastatic renal cell carcinoma
VEGFR1 肽疫苗治疗转移性肾细胞癌的 I 期试验
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[]
通讯作者:
共 12 条
Development of the HLA-A2 restricted multi-peptides vaccine for renal cell carcinoma.
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批准号:16H05466
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.07万
-
财政年份:2016
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负责人:UEMURA Hirotsugu
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依托单位:
Functional analysis of autophagy in PTEN/Atg7 double knockout mouse prostate cancer
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批准号:26670707
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2014
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负责人:UEMURA Hirotsugu
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依托单位:
Development of multi-peptide tumor vaccine for renal cell carcinoma
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批准号:25293336
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.56万
-
财政年份:2013
-
负责人:UEMURA Hirotsugu
-
依托单位:
Development of tailor-madepeptide vaccines for renal eell carcinoma
-
批准号:19390419
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.06万
-
财政年份:2007
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负责人:UEMURA Hirotsugu
-
依托单位:
Development new generation peptides derived from CA9 as tailar-made vaccines for renal cell carcinoma
-
批准号:16390468
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.22万
-
财政年份:2004
-
负责人:UEMURA Hirotsugu
-
依托单位:
MN/CA9 expression and VHL regulation in renal cell carcinoma
-
批准号:14571515
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:2002
-
负责人:UEMURA Hirotsugu
-
依托单位:
Active specific immunotherapy with MN\CA IX antigen peptide vaccines for renal cell carcinoma
-
批准号:13671671
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2001
-
负责人:UEMURA Hirotsugu
-
依托单位:
Specific immunotherapy targeting MN/CA9 tumor-associated antigen for renal cell carcinoma
-
批准号:11671576
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.5万
-
财政年份:1999
-
负责人:UEMURA Hirotsugu
-
依托单位:
Molecular detection of circulating renal cell carcinoma cells by RT-PCR
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批准号:09671643
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:1997
-
负责人:UEMURA Hirotsugu
-
依托单位:
Tools for active specific immunotherapy with anti-idiotype antibodies in human renal cell carcinoma
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批准号:07671748
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.47万
-
财政年份:1995
-
负责人:UEMURA Hirotsugu
-
依托单位:
海外基金