Effect of hesperidin on bone metabolism and the elucidation of its mechanism, through mevalonate synthesis

本研究的目的是通过甲氧戊酸的合成，检测橙皮苷对骨代谢的影响，并阐明其作用机制。在去卵巢小鼠股骨骨密度(BMD)和骨质量方面，联合服用橙皮苷和甲磺酸比单独服用橙皮苷有更好的效果。橙皮素以剂量依赖方式抑制RANKL诱导的RAW 264细胞破骨细胞形成。这些结果表明，橙皮苷调节胆固醇合成的下游信号通路，抑制骨吸收可能有助于改善骨代谢。

The purpose of this study was to examine effect of hesperidin on bone metabolism and the elucidation of its mechanism, through mevalonate synthesis. The concomitant intake of glucosylhesperidin and mevalonic acid had better effects in femur bone mineral density (BMD) and bone quality than glucosylhesperidin alone in ovariectomized mice. Hesperetin inhibited the osteoclast formation induced by RANKL in a dose-dependent manner in RAW 264 cells. These results indicate that hesperidin regulates the downstream signaling pathway of cholesterol synthesis, and the inhibition of bone resorption may contribute to the improvement bone metabolism.