Production of high quality organic micro-crystalsby using templated crystallization as nucleation trigger

在许多领域中需要制造细小的单峰晶体颗粒。在这项研究中，在空气/溶液界面上的成核现象的模板的效果进行了研究。明确了成核时间与模板界面进入过饱和溶液时间的关系，并对模板结晶的成核现象进行了研究。如果成核的时间可以通过使用模板效应来控制，则也可以产生单峰结晶颗粒。使用甘氨酸-水-L-亮氨酸（模板化合物）系统。结果表明，模板界面进入过饱和溶液的成核时间对控制粒径分布有重要意义。在过饱和溶液中形成新的模板界面作为成核触发器，诱导有目的的成核。通过使用该成核触发器，在空气/溶液界面处获得单峰结晶颗粒。

Fine monomodal crystalline particles are required to manufacture in many fields. In this study, the effect of template at the air/solution interface on the nucleation phenomena was investigated. And the relationship between nucleation timing and the timing in which the template interfaces were given into the supersaturated solution became clear, and nucleation phenomenon of templated crystallization was also investigated. If the timing of nucleation can be controlled by using template effects, monomodal crystalline particles can also be produced. The glycine - water - L-leucine (template compound) system was used. As the results, the nucleation timing of which template interface was given into the supersaturated solution was important for controlling size distribution. The formation of new template interface into the supersaturated solution acted as the nucleation trigger which induced purposeful nucleation. By using this nucleation trigger, monomodal crystalline particles were obtained at the air/solution interface.