Evaluation of exposure and absorption of insecticides, plasticizers and flame retardants in children in daily life

为测定暴露于有机磷化合物（10种杀虫剂和5种阻燃剂）和2种驱虫剂的儿童尿液代谢物，建立了一种精确的分析方法。此外，还研究了广泛用于杀虫剂的氟氯菊酯和氟氯菊酯的代谢物在大鼠体内的排泄动力学。尿液2,3,5,6-四氟苯甲酸和4-甲基-2,3,5,6-四氟苯甲醇分别被认为是监测跨氟菊酯和前氟菊酯暴露的最佳生物标志物。

An accurate and precise analytical method was developed for measurement of urinary metabolites in the children exposed to organophosphorus compounds (10 insecticides and 5 flame retardants) and 2 moth repellents. In addition, the urinary excretion kinetics of the metabolites of transfluthrin and profluthrin, which are widely used as insecticides, were examined in rats. Urinary 2,3,5,6-tetrafluorobenzoic acid and 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol were considered to be optimal biomarkers for monitoring transfluthrin and profluthrin exposure, respectively.