The analysis of serum cytokine and transcription factor level on the pathophysiology of neonatal asphyxia and intraventricular hemorrhage of extremely low birth weight infant

对5例有新生儿窒息的足月新生儿和3例早产儿及5例足月无新生儿窒息的早产儿和4例无新生儿窒息的早产儿在生后第0、1、2、3天测定外周血中细胞因子水平。15例接受消炎痛预防脑室出血的极低出生体重儿和11例未接受消炎痛治疗的极低出生体重儿在出生后第0、1、2、3、7、14天的外周血细胞因子谱进行了分析。前者的炎性细胞因子水平较后者低，且随时间推移而减少。这表明吲哚美辛可以抑制这些炎性细胞因子的产生，从而防止脑室出血。

We analyzed cytokine levels in peripheral blood from 5 full-term and 3 preterm infants with neonatal asphyxia and those from 5 full-term and 4 preterm infants without neonatal asphyxia on 0,1,2,3 day of life. We found that inflammatory cytokines were at higher level in the former group and decreased over time.In peripheral blood from 15 extremely low birth weight (ELBW) infants who received indomethacin for preventing intraventricular hemorrhage and 11 ELBW who did not receive indomethacin, we analyzed cytokine profiles on 0,1,2,3,7,14 day of life. Inflammatory cytokines are at lower levels and decreased over time in the former group than the later group. It suggests that indomethacin inhibits production of these inflammatory cytokines, and preventing a intraventricular hemorrhage.