Molecular mechanisms of left-right asymmetric morphogenesis in visceral organs and limb

关于内脏器官和肢体的左右不对称形态发生，我发现了以下分子机制：(1)接受Fgf信号的心内膜在心脏流出道形态发生中起重要作用。(2)心脏流出道的形态发生，除Fgf10外，还涉及多个Fgf因子。(3) pitx2的表达始于左外侧板中胚层，也始于肢芽的近轴中胚层细胞。(4)野生型和pitx2突变型胚胎左肢体背腹区表达pitx2的细胞增殖率不同。Pitx2抑制这些细胞的增殖。

About left-right asymmetric morphogenesis in visceral organs and limb, I discovered the following molecular mechanisms:（1）Endocardium, which receives Fgf signals, has important role in morphogenesis of heart outflow tract.（2）Morphogenesis of heart outflow tract involves several Fgf factors in addition to Fgf10.（3）Expression of Pitx2is initiated in left lateral plate mesoderm, and also begins at paraxial mesoderm cells in the limb bud.(4)Cell proliferation rate of Pitx2-expressing cells in dorso-ventral region of left limb is different between wild type and Pitx2mutant embryos. Pitx2 inhibits cell proliferation in these cells.