Effect of overexposure to estrogen in fetal period on immediate allergic reaction

胎儿期接触某些内分泌干扰物会影响生殖器官和免疫系统的发育。然而，胎儿期过度暴露于雌激素的影响尚不清楚。在本研究中，我们建立了表达胎盘特异性启动子驱动的芳香化酶的转基因小鼠模型（Arom TG小鼠），并研究了胎儿期过度暴露于雌激素对即刻过敏反应的影响。与野生型小鼠相比，Arom TG小鼠卵清蛋白诱导的活动性皮肤过敏反应增强。这一发现表明，在胎儿时期过度暴露于雌激素可能影响抗原呈递。

Exposure to some endocrine disruptors in fetal period can affect development of reproductive organs and the immune system. However, the effect of overexposure to estrogen in the fetal period remains unclear. In the current study, we generated a transgenic mice model that expressing aromatase driven by placenta-specific promoter(Arom TG mice) and investigated the effect of overexposure to estrogen in the fetal period on immediate allergic reaction. Ovalbumin-induced active cutaneous anaphylaxis in Arom TG mice was enhanced compared with that in wild-type mice.This finding suggests that overexposure to estrogen in the fetal period may affect antigen presentation.