Research of liver fibrosis associated with liver stem cells

在动物实验中已知肝祖细胞/干细胞中Delta样蛋白（DLK）-1的表达，而肝星状细胞中DLK 1的上调已被报道并暗示与纤维化有关。我检测了DLK 1在人体组织中的表达。结果表明，DLK 1在干细胞来源的肝癌中表达。提示DLK 1可能是肝癌干细胞标志物。

The expression of Delta-like protein(DLK)-1 in hepatic progenitor/stem cell has been known in animal experiments, whereas the upregulation of DLK1 in hepatic stellate cells has been reported and implied relation to fibrosis. I examined the expression of DLK1 in human tissue. As results, The expression of DLK1 was demonstrated in liver cancer associated with stem-cell origin. It was suggested that DLK1 could be cancer stem-cell marker of the liver.