Research in the interaction of dopaminergic functions in the basal ganglia

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Central dopamine (DA) systems are key players in the cerebral organization of behavior and various diseases. We show that stimulation of DA D_1/2 receptors in the accumbal shell decreased dorsal striatal DA efflux via a direct or indirect feed-forward loop involving shell, core, ventrolateral striatum (VLS) and dorsal striatum (DS): stimulation of D_1/2 receptors in the shell decreased DA efflux in the core; inhibition ofD_1/2 receptors in the core increased DA efflux in the VLS, and stimulation of D_1/2 receptors in the VLS decreased DA efflux in the DS. Finally, stimulation of D_1/2 receptors in the shell decreased DA efflux in the DS. Thus, we provide evidence in favor of the existence ofspiraling striato-nigro-striatal connections.