Neuron-Specific Function of N-TAF1, the disease causative gene of Hereditary Dystonia(DYT3)

我们之前发现了TAF1的神经元特异性亚型，TAF1是x连锁隐性肌张力障碍-帕金森病的致病基因。为了研究TAF1基因神经元特异性异构体的功能，我们在神经元和非神经元培养细胞系中进行了TAF1的过表达。我们证明了TAF1的定位模式在神经元细胞和非神经元细胞之间是不同的。我们使用siRNA敲低TAF1或N-TAF1。微阵列分析显示了一些可能受N-TAF1调控的候选基因。

We previously found a neuron-specific isoform of the TAF1, which is the disease causative gene of X-linked recessive dystonia-parkinsonism. To investigate the function of the neuron-specific isoform of the TAF1 gene, we carried out over-expression of TAF1 in neuronal and non-neuronal cultured cell lines. We demonstrated that the localization pattern of TAF1 is different between neuronal and non-neuronal cell. And we performed knockdown of either TAF1 or N-TAF1 using siRNA. The microarray analysis showed some candidate gene which might be regulated by N-TAF1.