Modulatory influence of ovariectomy on orofacial neuropathic pain in rats

采用von Frey法研究了goshajinkagan （GJG）对去卵巢眶下神经损伤大鼠机械超敏反应的影响。结果显示，慢性给药后，逐渐镇痛作用的发展潜力。此外，卵巢切除组与假手术组之间存在明显差异，卵巢切除本身可能会降低GJG的镇痛效果。在同一模型中对雌二醇（Es）替代作用的检查表明，Es可以加重急性炎症，同时减轻慢性疾病，如神经性疼痛。

We studied the effects of goshajinkigan (GJG) on mechanical hypersensitivity in ovariectomized rats with infraorbital nerve injury using the von Frey test. The results showed the potential development of gradual analgesic action with chronic administration of GJG. In addition, a difference was apparent between the ovariectomy and sham operation groups, and thus ovariectomy itself may reduce the analgesic effect induced by GJG. Examination of the effects of estradiol (Es) replacement in the same model indicated that Es acted to aggravate acute inflammation while mitigating chronic conditions such as neuropathic pain.