Fabrications of zinc-releasing biocement combining zinc calcium phosphate to calcium phosphate cement

近年来，释锌生物陶瓷因其良好的成骨能力而备受关注。因此，一些类型的含锌磷酸钙（例如，锌掺杂的磷酸三钙和锌取代的羟基磷灰石）并测定它们的成骨细胞反应。本研究以磷酸钙骨水泥（CPC）为载体，研究了磷酸锌钙（ZCP）对CPC的固化反应和成骨样细胞MC 3 T3-E1的作用。当CPC中加入10wt%的ZCP时，细胞增殖和碱性磷酸酶（ALP）活性增强。因此，ZCP添加适当比例的CPC对骨替代材料具有潜在的促进作用。

Recently, zinc-releasing bioceramics have been the focus of much attention owing to their bone-forming ability. Thus, some types of zinc-containing calcium phosphate (e.g., zinc-doped tricalcium phosphate and zinc-substituted hydroxyapatite) are examined and their osteoblastic cell responses determined. In this investigation, we studied the effects of zinc calcium phosphate(ZCP) derived from zinc phosphate incorporated into calcium phosphate cement (CPC) in terms of its setting reaction and MC3T3-E1 osteoblast-like cell responses. The proliferation of the cells and alkaline phosphatase (ALP) activity were enhanced when 10 wt% ZCP was added to CPC. Taken together, ZCP added CPC at an appropriate fraction has a potentpromotive effect on bone substitute biomaterials.