Visualization of chromosome aneuploidy in living embryo

卵母细胞和早期胚胎中的染色体非整倍体是导致早期妊娠丢失的主要原因，并在出生后引起严重的染色体紊乱，如唐氏综合征。然而，由于早期胚胎固有的实验限制，染色体异常的机制仍然是个谜。在这项研究中，我们建立了一种新的方法，通过开发与特定染色体结合的荧光探针来显示活胚胎中的染色体非整倍体。

Chromosomal aneuploidy in oocyte and early embryo is major cause of early pregnancy loss and evokes severe chromosome disorder such as Down syndrome after birth. However, the mechanisms for the chromosome abnormality were still enigmatic due to the experimental limitations inherent to the early embryo. In this study, we established a new protocol to visualize the chromosomal aneuploidy in living embryo by developing the fluorescently probe that binds to the specific chromosomes.