Promotion of neuromuscular regeneration by transplantation of bone marrow and/ or muscle satellite cells

研究了热休克蛋白72（HSP 72）表达增强的骨髓和/或肌肉卫星细胞移植对肌肉和神经再生的影响。将从绿色小鼠中取样的这些细胞移植到i. P.或I.通过颈静脉注射给肌肉注射布比卡因造成后肢肌肉损伤的小鼠。在损伤的肌肉中检测到移植的细胞，而不是在对侧完整的肌肉中。由于受体小鼠对移植细胞的排斥，这种治疗促进再生的效果尚不清楚。然而，根据肌肉横截面的形态学特性和基因表达的分析，认为细胞移植的有益效果。

Effects of transplantation of bone marrow and/ or muscle satellite cells with enhanced expression of heat shock protein 72(HSP72) on the regeneration of muscle and nerve were studied. These cells sampled from green mice were transplanted i. p. or i. v. through the jugular vein to mouse with hindlimb muscle injury caused by intramuscular injection of bupivacaine. The transplanted cells were detected in the injured muscle, not in the contralateral intact muscle. Effects of such treatment for promotion of regeneration were not clear due to the rejection of transplanted cells by the recipient mouse. However, it was suggested that beneficial effects of cell transplantation according to the analyses of morphological properties of muscle cross-section and gene expression.