The role of gut bacterial flora in the development of sarcopenia

为了阐明与衰老相关的骨骼肌减少症是否取决于肠道菌群维持的肠道功能，我们研究了抗生素治疗对骨骼肌损伤和恢复过程以及骨骼肌废用性萎缩及其重新加载后恢复过程的影响，抗生素治疗消除了大部分肠道菌群。我们发现，细菌消除导致骨骼肌从废用性萎缩中恢复的过程显著延迟。在另一项实验中，我们发现与LPS不同，给抗生素治疗的小鼠注射肽聚糖（PGN）在逆转化学诱导的肌肉损伤延迟恢复方面并不有效。

In order to clarify whether sarcopenia associated with ageing depends upon gut function maintained by gut flora, we investigated the effect of antibiotics treatment, by which majority of gut flora was eliminated, on the process of skeletal muscle damage and recovery and the process of skeletal muscle disuse atrophy and its recovery after reloading. We found that bacterial elimination resulted in a significant delay in the process of skeletal muscle recovery from disuse atrophy. In a separate experiment, we found that unlike LPS, peptide glycan (PGN)administration to antibiotics treated mice was not as effective in reversing the delayed recovery from chemically induced muscle damage.