Creation of the anti-neoplasmic acrylate-nanopolymer with amino acid

以必需氨基酸和氰基丙烯酸正丁酯药物为原料，合成了新型氨基酸纳米聚合物。该纳米颗粒对淋巴肿瘤细胞和上皮肿瘤细胞株的抗肿瘤作用与时间和浓度有关。这些纳米颗粒分别与Gly、Asp、Asn和His偶联，具有较强的抗肿瘤作用。该纳米颗粒激活caspase 8和caspase 3，随后通过DNA切割诱导凋亡细胞死亡。在体内，该纳米颗粒通过移植到裸鼠体内，显著抑制肿瘤的发生。这种与氨基酸偶联的纳米聚合物有望成为治疗癌症和预防癌症的新方法。

New nanopolymers with amino acid were newly synthesized by using essential amino acids and n-butylcyanoacrylate medicine.This nano particle showed antitumor effects dependent on time and concentration to the lymphatic tumor cell and epithelium tumor cell strains. The antineoplasmic effect Such nano-particles, showd strong effect, were those coupled with Gly, Asp, Asn, and His.This nano particle activated caspases 8 and caspases 3 were activated, then the apoptosis's cell death is induced subsequently by DNA cleavage. In vivo, this nano particle inhibited notably tumorigenesis by transplantation to a nude mice.This nano polymer coupled with amino acid is hopeful as a new treatment of cancers also cancer prevention.