CYP3A4 induction-associated dyslipidemia : a new risk factor for lifestyle disease

在这项研究中，我们获得了以下发现：1)小鼠Cyp3a11和人Cyp3A4在肝细胞中的表达受细胞胆固醇水平的调节；2)细胞胆固醇水平降低激活的SREBP-2下调了细胞色素P3A基因的表达；3)胆固醇代谢产物氧固醇激活的LXRα反式激活了细胞色素P3A基因的表达。此外，我们还证明了腺病毒过表达的CYP3A4改变了培养的小鼠肝细胞中与脂质代谢相关的基因的表达谱。

In this study, we have obtained following findings : 1)the expressions of mouse Cyp3a11 and human CYP3A4 in hepatocytes are modulated by cellular cholesterol levels, 2)SREBP-2 activated by reduced cellular cholesterol levels down-regulates the expressions of CYP3A genes, 3)LXRα, which is activated by cholesterol metabolites oxysterols, transactivates the expression of CYP3A genes. Moreover, we demonstrated that the adenoviral overexpression of CYP3A4 changed the expression profile of genes associated with lipid metabolism in cultured mouse hepatocytes.