CD1/lipid immunity-based vaccines against AIDS

针对人类免疫缺陷病毒感染的有效蛋白质疫苗仍有待建立。困难产生于频繁的逃逸突变，因此，识别不允许任意突变的T细胞表位是至关重要的。我们已经在细胞培养和人类艾滋病的猴子模型中鉴定了肉豆蔻酰化Nef多肽(脂多肽)对细胞毒T细胞的反应。由于蛋白质肉豆蔻酸化发生在高度保守的氨基酸序列中，并且对毒力至关重要，因此本研究强调了脂肽可能成为抗艾滋病疫苗的理想靶点的可能性。

Effective protein vaccines against infection with human immunodeficiency virus remain to be established. The difficulties arise from the frequent escape mutations, and thus, identification of T cell epitopes that admit of no arbitrary mutations is crucial. We have identified cytotoxic T cell responses to myristoylated Nef peptides(lipopeptides) both in cell culture and in the monkey model of human AIDS. Because the protein myristoylation occurs in highly conserved amino acid sequences and is critical for virulence, the present study underscored the possibility that lipopeptides could be an ideal target for anti-AIDS vaccines.