Effect of senescent adipose tissue on periodontal disease states

我们研究了新鉴定的脂肪因子apelin是否对脂多糖（LPS）处理的巨噬细胞中的炎症反应具有抑制作用。 apelin预处理显著减少LPS处理的巨噬细胞样细胞系J774.1细胞中促炎细胞因子的产生。 此外，apelin预处理显著降低LPS诱导的p38 MAPK和JNK的磷酸化，但不降低ERK的磷酸化。 据我们所知，这是首次报道爱帕琳肽家族对巨噬细胞中的细菌LPS刺激具有抗炎作用。

we investigated whether newly identified adipokine apelin had an inhibitory effect on inflammatory response in lipopolysaccharide (LPS) -treated macrophage. Pretreatment with apelin significantly reduced the production of proinflammatory cytokines in LPS-treated macrophage-like cell line, J774.1 cell. In addition, apelin pretreatment significantly reduced the LPS-induced phosphorylation of p38 MAPK and JNK, but not ERK. To the best of our knowledge, this is the first report that the apelin peptide family has anti-inflammatory effects against bacterial LPS stimulation in macrophages.