Effects of deviated food habit on autoimmune and allergic diseases, and their association with intestinal microflora

为探讨饮食习惯改变与自身免疫性疾病的相关性，以及饮食改变对疾病的不良影响是否与肠道菌群有关，将风湿性关节炎和1型糖尿病模型小鼠DBA1/J和NOD小鼠分别饲喂高脂葡萄糖饲料(HFGD)。经HFGD处理的两个品系的小鼠的发病率和患病程度均低于对照组，提示HFGD对这些实验模型中的疾病没有促进作用。这些转基因小鼠被删除了一种与自身免疫性疾病相关的特定基因，并被喂以高脂饮食(HFD)，并监测了血清中炎症细胞因子的水平。基因敲除小鼠的细胞因子水平高于WT小鼠，但HFD对两组小鼠的细胞因子水平均无影响。这些结果表明，在本实验模型中，食物的改变不会影响疾病的发生。

To determine the correlation between deviated food habit and autoimmune diseases, and whether the wrong effects of food change on the disease were associated with the intestinal microflora, DBA1/J and NOD mice, which are model mice for rheumatism arthritis and type1 diabetes, respectively, were fed with high fat glucose diet (HFGD). Both strains of mice treated with HFGD showed less incidence and degree of illness than the control diet group, suggesting that HFGD does not have the enhancing effect for the diseases in these experiment models. The genetically modified mice, which are deleted a specific gene related to an autoimmune disease, were fed with high fat diet (HFD), and monitored serum levels of inflammatory cytokines. The cytokine levels were higher in the kockout mice than WT mice, however, HFD did not show any effects on the cytokine levels in both group of mice. These results indicated the change of food could not affect the illness in the experimental models used here.