Development of Novel Separation Method Based on Specific Distribution Behavior of Fluidic Solvents in a Capillary Tube

我们研究了一个特定的微流体行为所表现出的混合溶剂溶液在一个微空间，管径向分布现象（TRDP）。在水-亲水/疏水有机溶剂、水-表面活性剂、水-离子液体、氟/有机溶剂等三元溶液体系中观察到了特定的流体行为。当混合均匀的溶液在一定条件下被输送到微空间时，溶剂分子在微空间中呈放射状分布，产生具有动态液-液界面的内相和外相。通过荧光显微镜、相图构建和溶质在毛细管中的洗脱行为对TRDP进行了初步评价。基于TRDP的毛细管色谱，称为管径向分布色谱（TRDC），其中外相在层流条件下充当伪固定相，已被开发为TRDP的应用之一。我们还研究了基于TRDP的萃取、化学反应和混合过程，分别称为管径向分布萃取（TRDE）、管径向分布反应（TRDR）和管径向分布混合（TRDM）。通过本研究，对TRDP、TRDC、TRDE、TRDR和TRDM的概念和实验结果进行了研究。

We examined a specific microfluidic behavior exhibited by mixed-solvent solutions in a microspace, coined as the tube radial distribution phenomenon (TRDP). The specific fluidic behavior was observed in the following solution systems : ternary water-hydrophilic/hydrophobic organic solvents, water-surfactant、 water-ionic liquid, and fluorous/organic solvents. When the mixed homogeneous solutions were delivered into a microspace under certain conditions, the solvent molecules were radially distributed in the microspace, generating inner and outer phases with a kinetic liquid-liquid interface. The TRDP was fundamentally evaluated by fluorescence microscopy, phase diagrams construction, and the elution behaviors of solutes in a capillary tube. A TRDP-based capillary chromatography, referred to as tube radial distribution chromatography (TRDC), where the outer phase serves as a pseudo-stationary phase under laminar flow conditions, has been developed as one of the applications of TRDP. We have also investigated TRDP-based extraction, chemical reaction, and mixing processes, coined as tube radial distribution extraction (TRDE), tube radial distribution reaction (TRDR), and tube radial distribution mixing (TRDM), respectively. The concept and experimental findings regarding TRDP, TRDC, TRDE, TRDR, and TRDM were investigated through this study.