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Development of the new treatment, prophylaxis of the phylum Apicomplexa

Development of the new treatment, prophylaxis of the phylum Apicomplexa
开发新的治疗方法，预防顶复门
批准号：
23580445
负责人：
SASAI Kazumi
金额：
$3.41万
依托单位：
Osaka Prefecture University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2013
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23580445/
关键词：
ApicomplexaApical complexモノクローナル抗体感染防御Cryptosporidiumapical complexElongation factor 1αchicken mABマラリア侵入抑制交差性Eimeria tenellaCryptosporidium parvumPlasmodium vinckei鶏型モノクローナル抗体抗原解析

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中文摘要
翻译
用单克隆抗体（mAB）对识别的细小隐孢子虫和伯氏疟原虫根尖复合体抗原进行分析。由此推测，EF-1a可能在寄生虫侵染宿主细胞过程中发挥了重要作用。因此，单抗识别的抗原有可能成为隐孢子虫病和疟疾的候选疫苗抗原。
英文摘要
The antigens in apical complex of Cryptosppridium parvum and Plasmodium berghei recognized were analyzed by monoclonal antibody (mAB) .From these results, the possibility that EF-1a played the role that was important to the host cells invasion due to the parasitic worm was suggested.Thus, the possibility that the antigen which mAB recognized was the antigen which could become a vaccine candidate for the cryptosporidiosis and Malaria was suggested.
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会议论文
Infectivity of Cryptosporidiumandersoni Kawatabi type relative to thesmall number of oocysts in immunodeficient and immunocompetent neonatal and adult mice
安氏隐孢子虫川田型相对于免疫缺陷和免疫功能正常的新生和成年小鼠中少量卵囊的感染性
DOI： 10.1016/j.parint.2012.11.001
发表时间： 2013
期刊： Parasitol Int.2013
影响因子： --
作者： [Nagano-Koyashiki S, Matsubayashi M(CA), Kimata I, Furuya M, Tani H, Sasai K]
通讯作者： Sasai K
Control of food poisoning using food and feed additives of chicken monoclonal antibodies.
  • 批准号：
    20580357
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $3.0万
  • 财政年份：
    2008
  • 负责人：
    SASAI Kazumi
  • 依托单位：
    Osaka Prefecture University
Defence mechanism against Coccidia using common antigens related with host cell invasion
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