The cAMP elevation and CREB activation stimulates DNA repair capacity in skin and neuronal cells.

开展了一项基础研究，以开发一种新的方法来预防日光诱导的皮肤癌和黑色素瘤，以及色素性干皮病(XP)患者的进行性神经系统疾病，使用能够通过提高细胞cAMP水平和CREB活性来刺激DNA修复能力的药物。我们的结果提示DBcAMP可以刺激神经母细胞瘤细胞的DNA修复能力。环嘌呤类药物可能与XP神经系统疾病有关。因此，我们建立了一种新型的针对环嘌呤的单抗，以确定DBcAMP是否也能刺激环嘌呤的修复能力。

A basic research was performed to develop a novel method in preventing sun-induced skin cancers and melanomas, and progressive neurological disease in xeroderma pigmentosum (XP) patients using agents that can stimulate DNA repair capacity through the elevation of cellular cAMP level and CREB activity. Our results suggested that DBcAMP can stimulate DNA repair capacity in neuroblastoma cells.Cyclopurines are candidates to be involved with XP neurological disease. Thus, we established a novel monoclonal antibody specific for a type of cyclopurine, cyclo-dA, in order to determine whether DBcAMP can also stimulate repair capacity for cyclopurines.